Degeneration of the knee joint refers to the decline in function of the meniscus, ligaments, and synovial and bursal structures of the knee joint. The degeneration of the knee joint is a comprehensive knee joint change that requires treatment in a variety of ways. If the pain is severe and the movement is limited, oral tonics are needed to strengthen the tendons and activate the blood; if the pain and swelling are obvious and the joint movement is normal, oral tonics are needed to relieve pain; if the joint pain and swelling are relatively mild but the joint strength is insufficient, oral tonics are needed to strengthen the tendons. In the knee joint, fumigation and external washing treatment with Haidongpi Tang, together with manual massage, acupuncture treatment, and physical treatment methods such as ultrasonic therapy, pulsed electric therapy, and Chinese herbal medicine ion introduction therapy, etc., in addition to appropriate joint function exercises, can improve joint degeneration.