Condyloma acuminatum is caused by HPV infection, the disease recurs for many reasons, mainly the following: 1, HPV subclinical infection and latent infection: the former is not clinically identifiable lesions, need to be observed with the aid of white acetate and other auxiliary means, their histology and cytology have typical HPV infection changes; the latter is the HPV infection of the skin does not cause any clinical symptoms, white acetate test (- ), cytological and histological examinations are normal, but the infection of the virus can be detected by PCR and other methods. These two infections are difficult to be completely cleared by conventional treatment, and will develop into naked eye visible lesions under conditions such as decreased immunity of the organism, which is the main cause of recurrence. 2, low immunity of the body. 3, viral load: fluorescence quantitative PCR test found that the recurrence of condyloma acuminata patients infected with a high local viral replication. 4, accompanied by other sexually transmitted diseases. 5, again the infection contact: again the high-risk sexual behavior and contact with untreated infected sexual partners can also cause recurrence. 6, male circumcision is too long. 7, psychological factors: the majority of patients can have depression and anxiety and other psychological disorders, the patient’s bad mood can cause a decline in the body’s cellular immune function, so that the virus replication increased. Some patients take incorrect excessive cleaning means, but lead to the destruction of the local skin mucous membrane barrier, easy to cause recurrence.