Papillary lesions of the common bile duct are one type of intraductal papillary tumor disease. Intracholedochal papillary tumor is a general term for papillary benign and malignant tumors occurring in the hepatic bile ducts, which are divided into limited and diffuse multiple ones. The etiology is not clear, and may be related to inflammation, stones, abnormal pancreaticobiliary flow, cysts and so on. Generally benign, but easy to recurrence, high rate of malignant transformation. Symptoms of early atypical, abdominal pain and discomfort, anorexia belching (hiccups), etc.; disease progression of biliary obstruction with epigastric pain, jaundice, fever and other symptoms of acute cholangitis, combined with biliary hemorrhage with blood in the stool, a small number of can be induced pancreatitis; the late stage can be biliary cirrhosis, portal hypertension and hepatic failure, malignant can be metastasized. The treatment of papillary lesions in common bile duct is mainly based on surgery, limited bile duct and liver tissue resection can be performed, and bile duct jejunum anastomosis or liver transplantation can be considered in extensive cases; choledochoscopic coagulation, cutting and other treatments are effective; ERCP and nasocholestial drainage are feasible for those who don’t have surgery, and built-in stenting of bile ducts are also available. It is difficult to diagnose and treat papillary tumor in bile ducts, so it is necessary to consult doctor as early as possible for examination and timely treatment if there are uncomfortable symptoms.