Aortic sinus widening may not be a disease in itself, but a secondary damage caused by other large artery disease, or poorly controlled hypertension, so aortic sinus widening is not harmful in itself. However, if aortic sinus widening leads to changes in coronary opening pressure, it may lead to ischemic cardiomyopathy, such as exertional angina, or even myocardial infarction. Because widening of the aortic sinus can lead to an enlarged annulus, the valve cannot be completely closed, and aortic regurgitation can occur, which can increase the pressure in the left ventricle and make the heart’s left heart load heavier and heavier. In addition, the widening of the aortic sinus will cause changes in the pressure of the inner and outer membranes of the ascending aorta, making it easy to develop aortic aneurysm or aortic coarctation, which can directly lead to death once these two diseases induce aortic rupture.