The prevalence of chronic kidney disease has reached more than 10% and is increasingly becoming a serious social public health problem. A significant number of patients are women of childbearing age, and often female patients come to ask about pregnancy. Some of our friends give up childbirth for fear of kidney function damage, and we hear more about heroic mothers who insist on getting pregnant when their kidney disease is not under control, and we often encounter cases of early termination of pregnancy before the tenth month of pregnancy in patients with kidney disease, and premature babies who have to spend their first days in the pediatric care unit. The mother also risks dialysis …… Is it possible to have a pregnancy with kidney disease? How can we get through the pregnancy and delivery and give birth to a healthy baby and a happy and perfect family? Let’s talk about this issue from a professional perspective. First of all, we need to understand the relationship between pregnancy and kidney. Pregnancy increases the burden on the kidneys leading to overload, thus the serum creatinine level of pregnant women is lower than normal, generally considered to be more than 70 μmol/L is highly indicative of the presence of reduced kidney function. Many obstetric and gynecological diseases have adverse effects on the kidneys, such as gestational hypertensive syndrome, placental abruption and diffuse intravascular coagulation, which can lead to severe renal damage and even acute renal failure. On the other hand, pregnancy can also aggravate the progression of existing kidney disease, whether it is chronic nephritis, rheumatic kidney damage, polycystic kidney, kidney stones or hereditary kidney disease, all of which may cause a dramatic deterioration of kidney function, which also leads to a significant increase in complications of pregnancy and endangers the safety of the pregnant woman and the fetus. According to literature analysis and our hospital experience, the incidence of preterm delivery, intrauterine distress, fetal death, growth retardation and neonatal asphyxia in fetuses and newborns with kidney disease is significantly higher, and the complications in pregnant women are significantly higher than those in general maternity. Can kidney disease patients not have their own babies like ordinary people? The answer is certainly not. Under certain conditions, patients with kidney disease can still get pregnant and give birth. It is now considered that before pregnancy, blood pressure and proteinuria are well controlled and renal function is normal or serum creatinine.