Although ketoconazole lotion and selenium disulfide lotion both have antifungal effects, there are some differences between the two in terms of drug efficacy, drug composition and adverse reactions. It is recommended that patients use both drugs under the guidance of a doctor. 1. drug efficacy: ketoconazole in addition to anti-fungal, but also as a gynecological anti-infective drugs and sterilization drugs, such as the treatment of vaginal candida infection. Selenium disulfide has a stronger role in oil control and fat removal, as well as an antifungal effect. 2. Composition: Ketoconazole lotion is mainly composed of ketoconazole. Selenium disulfide is mainly selenium disulfide. 3. Adverse reactions: ketoconazole lotion’s adverse reactions are burning sensation and irritation of the skin, which may also lead to acne, hair loss, hair discoloration, eye irritation and so on. Adverse reactions to selenium disulfide lotion are contact dermatitis, dry scalp, and discoloration. 4. Contraindications: ketoconazole lotion can be used on the external genital area, while selenium disulfide lotion is contraindicated for the external genital area. It is recommended that patients who need to use ketoconazole lotion or selenium disulfide lotion, go to the regular hospital in time to make a clear diagnosis, under the guidance of a professional doctor reasonable medication.