The cause of hypospadias is more complex, including factors related to the pregnant mother, as follows: 1, environmental factors: such as rural areas, the use of organophosphorus pesticides including dichlorvos, 666, etc., pregnant women’s daily exposure to pesticide residues of fruits and vegetables more, can lead to hypospadias; 2, genetic factors: by reviewing the relevant literature, it can be proved that hypospadias is related to genetics; 3, the use of certain drugs in early pregnancy: such as the use of progesterone, estrogen and other fetal preservation, can lead to hypospadias.