Uremic pruritus is one of the most common complications in patients with end-stage renal disease. The formation of uremic pruritus includes uremic and non-uremic factors, and is a complex pathophysiologic process related to high phosphorus, inflammatory response, and dry skin syndrome.
Blood phosphorus is poorly controlled in uremic patients, and the higher the blood phosphorus level, the greater the probability of generalized itching. It is partly believed that generalized itching in uremia may be a systemic inflammatory response, and C-reactive protein is significantly elevated in patients who develop itching. While C-reactive protein is a more sensitive indicator for determining the inflammatory response, generalized itching in uremia is also related to the inflammatory response.
In addition, it may also be due to dry skin, due to the patient’s sebaceous glands and sweat glands of atrophy, the PH value of the skin stratum corneum increased, while the epidermis in the concentration of vitamin A increased, etc., may be induced by generalized itching.
Patients with uremia generalized itching should go to the hospital in a timely manner, under the guidance of a professional physician to clarify the cause and timely treatment.