The causes of wrist soreness and weakness with osteoarthritis, carpal tunnel syndrome, neurogenic cervical spondylosis, etc., need to choose the appropriate medication for the cause, should follow the doctor’s instructions for medication. 1. For osteoarthritis, oral ibuprofen, celecoxib and other non-steroidal anti-inflammatory drugs can control inflammation and relieve symptoms. 2. For carpal tunnel syndrome or rheumatoid diseases, oral glucocorticoids such as prednisone can reduce inflammation and swelling and help relieve symptoms. 3. For nerve root cervical spondylosis, neurotrophic drugs such as methylcobalamin and dexamethasone can be taken orally to reduce the edema of the nerve roots, which can help to alleviate the feeling of soreness and weakness. It is recommended that people with wrist pain and weakness go to a regular hospital in a timely manner to clarify the cause of the disease and standardize the treatment under the guidance of the doctor, so as not to delay the condition, do not blindly use drugs.