In patients with severe constipation, organic constipation is mainly treated for the cause, while patients with functional constipation should be treated with medication, biofeedback or surgery while adjusting diet, increasing exercise and other life adjustments. 1.Medication: mainly includes laxatives and gastrointestinal stimulants. ①Laxatives: according to the degree of constipation, laxatives can be selected. Chronic constipation with bloating laxatives is appropriate, only when necessary to choose stimulating laxatives (such as rhubarb, senna, phenolphthalein, etc.), not long-term use. Acute constipation can choose salt laxatives (such as magnesium sulfate), stimulant laxatives and lubricating laxatives (such as paraffin, glycerin), but not for more than a week. Long-term chronic constipation, especially those who cause fecal impaction, can use the method of enema. ② Prokinetic drugs: commonly used drugs are mosapride and itopride, whose mechanism of action is to stimulate the intestinal interosseous neurons, promote gastrointestinal smooth muscle peristalsis, and promote the operation of the small and large intestine. 2.Biofeedback therapy: Through manometry and electromyography equipment, patients can intuitively perceive the functional state of the pelvic floor muscles for defecation, and “understand” how to relax the pelvic floor muscles during defecation, while increasing intra-abdominal pressure to achieve defecation therapy. 3.Surgical treatment: If the chronic transmission type constipation is diagnosed after the appeal treatment is ineffective, subtotal colectomy and ileorectal anastomosis can be used. In summary, the treatment of severe constipation is mainly life regulation colleagues for drug, biofeedback or surgical treatment. Therefore, patients should go to the hospital as early as possible to find the cause of the disease, and then choose the appropriate treatment according to the cause and condition.