Nexium is an esomeprazole magnesium enteric-coated tablet, formerly known as esomeprazole magnesium enteric-coated tablet, manufactured by AstraZeneca Pharmaceuticals Ltd. It is an antacid of the proton pump inhibitor class and is used in the treatment of gastroesophageal reflux disease and Helicobacter pylori eradication. The drug needs to be taken before meals. Nexium is unstable to acid and is formulated in an enteric-coated form to avoid destruction by stomach acid. The drug in enteric-coated form does not dissolve easily in the acidic environment of the stomach. The drug enters the small intestine with gastric peristalsis and disintegrates and is released in the alkaline environment of the small intestine, so in order to make it reach the small intestine as soon as possible, it is recommended to take it at least half an hour before a meal. If taken after a meal, the food in the stomach and the drug remain in the stomach for a long time, delaying the time for the drug to reach the small intestine, while a small amount of the drug is destroyed by stomach acid, making the drug lose its original efficacy. In addition, the drug should be swallowed whole and should not be chewed or crushed. For patients with swallowing difficulties, the tablet can be dissolved in half a glass of carbonate-free water, stirred until the tablet is completely dissolved, and if it has to be taken orally, it should be taken immediately or within 30 minutes, and then rinsed with half a glass of water and drunk; it can also be injected directly through a gastric tube. In summary, the generic name of Nexium is Esomeprazole Magnesium Enteric Tablets, which is an enteric-coated granule that needs to be taken before meals and should be swallowed whole as much as possible and should not be chewed or crushed. The specific medication, please combine with clinical, to the doctor’s face to face guidance shall prevail.