Painful urination is usually caused by urethritis, prostatitis, cystitis, urinary tract stones, bladder tuberculosis, pyelonephritis and other causes. So what kind of medicine do you usually take when you have painful urination? The painful urine is mostly seen in urinary tract infections, inflammatory reactions caused by painful urination, you can eat antibiotic drugs to give anti-inflammatory treatment, mainly levofloxacin, or cefotaxime sodium, amoxicillin and other antibiotics. If the urine pain is caused by prostate disease, you can use finasteride drugs to inhibit prostate enlargement. If the painful urination is caused by stones, you can take drugs for stone removal, such as stone removal soup, to treat the symptoms.