Tetanus of newborn is an acute infectious disease caused by the invasion of Clostridium tetani from the umbilicus. It often develops around 7 days after birth and is characterized clinically by tonic spasms of the skeletal muscles of the whole body and closed teeth, hence the name “umbilical wind”, “seven-day wind” and “locked mouth wind”. Pathogenesis: Clostridium tetani is gram-positive anaerobic bacteria, widely distributed in soil, dust and human and animal feces. Its bacterium resistance is very strong, in the soil without sunlight can be decades immortal, can withstand boiling 60min, dry heat 150 ℃ 1h, 5% phenol 10 to 15h, need high pressure disinfection, with iodine and other disinfectants containing iodine or ethylene peroxide, gas disinfectant epoxide acetylene to kill it. Infection is often caused by the use of unsterilized scissors and string to break and tie the umbilical cord; when the hands of the midwife or the cotton gauze covering the umbilical cord stump are not strictly sterilized, Clostridium tetani can be invaded. Neonatal tetanus can occasionally occur after poor disinfection for vaccination. Clostridium tetani is not a tissue-invasive bacterium, and only causes disease through tetanus spasm toxin; tetanus toxin is the second-ranked toxin among known toxins, second only to botulinum toxin, and its lethal dose is about 10-6 mg/kg.