If pediatric mesenteric lymphadenitis has been diagnosed, anti-infective treatment with relatively effective antibiotics can be selected according to the child’s clinical situation, and the common antibiotics are mainly cephalosporins II and III. The child’s temperature, abdominal symptoms, signs and blood picture should be closely observed, and attention should be paid to rest and intravenous rehydration to correct the water-electrolyte imbalance. Symptomatic treatment should be given for symptoms such as fever and abdominal pain. In addition to drug treatment, we should also pay attention to the child’s diet, avoid cold food, greasy food, strengthen exercise, improve immunity, and use hot water bags to apply local heat to the abdomen when the child has abdominal pain.