Easily agitated and irritable moods are more common in clinical practice in depression, anxiety disorders or mania. When the patient is mainly depressed and slow in thinking, often accompanied by irritable mood, easily agitated and easily provoked, and feels low self-esteem and has self-injury and suicidal thoughts, depression is more suspected. Once the diagnosis of depression is made, systematic antidepressant medication is required and good treatment results can be achieved. In addition, patients with anxiety disorders can also appear agitated and irritable, which is because under the influence of worry and fear, the patient’s plant nerve function is disturbed, which stimulates sympathetic excitation, and the patient appears highly alert and has symptoms such as irritability, irritability and less sleep. Therefore, once anxiety disorder is diagnosed, the applied anti-anxiety drugs or psychotherapy can achieve good treatment effect. For bipolar disorder patients can also appear agitation, irritability, mainly when the patient’s emotions are high, thinking run away, in the process of communication with others after being blocked can appear this performance, often with emotional stabilizers and antipsychotic drugs systemic treatment, can achieve good therapeutic effect.