The most common cause of mental irritability is anxiety caused by work pressure and external emotional stimulation, which requires self-regulation, arranging work and rest time, and using sedative medication if necessary. Physical diseases can also induce symptoms of anxiety such as hyperthyroidism and adrenal tumors, which can be diagnosed through thyroid function and adrenal CT tests and treated for the original disease. Women may experience emotional irritability during menstruation, which may be caused by endocrine imbalance during the menstrual cycle, resulting in plant nerve dysfunction, so the main thing is to pay attention to work and rest, and maintain an optimistic mood. Women may experience irritability after pregnancy, which may be related to the change of hormone level after pregnancy.