If a person is always irritable, it is clinically necessary to perfect the examination of body hormones such as thyroid hormones to exclude the influence of body hormones on the patient’s mood. If the organic disease is ruled out and the patient still shows irritability, then you can consider whether it is an anxiety disorder. If this state does affect the patient particularly, in addition to psychotherapy, medication has a very important role in the improvement of the whole state. You can choose anti-anxiety medications such as buspirone and tandospirone to control the patient’s irritability, or you can choose sertraline, fluoxetine, paroxetine, citalopram, escitalopram, etc., antidepressants with anti-anxiety to control the patient’s state and maximize the patient’s quality of life.