How should gallbladder stones combined with bile duct stones be treated? There are different standard answers to this question at different times. In the last century, open cholecystectomy, choledochotomy and T-tube drainage were once the classic treatment for patients with gallbladder stones combined with bile duct stones, but the surgery was very traumatic and the recovery was slow. In recent years, with the advancement of minimally invasive surgical techniques, laparoscopic combined with choledochoscopic surgery has been realized, which not only overcomes the shortcomings of open surgery, but also avoids the disadvantages of EST surgery in destroying the duodenal papillary sphincter. It has become the best treatment option for gallbladder stones combined with bile duct stones.