Normal adult daily urine volume is 1000-1500 ml, clinically it is considered as polyuria when the 24-hour urine volume is more than 2500 ml, and it needs to be considered as enuresis when the 24-hour urine volume is more than 5-10 liters. Polyuria can be manifested as temporary polyuria and persistent polyuria. Transient polyuria is usually due to excessive water intake or diuretics. Persistent polyuria is commonly associated with endocrine metabolic disorders, renal diseases, psychiatric factors and genetic factors. The most common endocrine metabolic disorder is pituitary uremia. Urachidrosis can occur at any age, but it is more common in adolescents, and the incidence is higher in males than females. The main clinical manifestations of uremia are polyuria, intense thirst, the need to drink a lot of water, especially like to drink cold drinks, often the onset of the disease is urgent, usually the date of onset can be clear, 24-hour urine volume can be as much as 5-10 liters, but at most not more than 18 liters, urine specific gravity is low, often below 1.005, urine color is as light as water. If patients have the above symptoms, they need to visit the endocrinology department of the hospital, measure the 24-hour urine volume, and improve the urine specific gravity, cranial pituitary MRI and endocrine function tests such as water prohibition and pressure test to further clarify the diagnosis. The treatment of uremia is mainly based on drug therapy, such as the commonly used antidiuretic hormone desmopressin acetate tablets (mydriatic tablets), but if it is caused by intracranial tumors or other systemic diseases such as nephropathy, surgical treatment and active treatment of the original disease are required. With adequate hydration and antidiuretic treatment, the general health of patients with uremia is not seriously affected, and they can usually maintain a normal life with little impact on their life expectancy. However, if excessive water loss occurs due to dehydration, hot environment, reduced water intake, or vomiting or diarrhea, rapid and severe dehydration can occur, which may be followed by cramps or coma in older patients. Untreated patients may also develop hydronephrosis, ureteral edema, and giant bladder disease due to prolonged discharge of large amounts of urine.