For patients with advanced prostate cancer, it has been medically proven that there is no longer a complete cure. And to make matters worse, early detection of prostate cancer is very difficult, and once a patient visits the hospital because of symptoms such as poor urination, hematuria or bone pain, the cancer is often already advanced. However, fortunately, prostate cancers themselves have a very fatal weakness, which is that they depend on androgens to provide nutrition for their growth. Once the androgens are removed, most prostate cancers gradually shrink or even disappear and can be maintained for a long time. In 1941, an American doctor named Huggins discovered this hormone-dependent nature of prostate cancer and invented orchiectomy to remove androgens to treat advanced prostate cancer, which was so successful that it effectively treated many prostate cancer patients and won the 1966 Nobel Prize in Medicine. To this day, bilateral orchiectomy has become the gold standard of endocrine therapy for advanced prostate cancer. If a patient is unwilling or unable to undergo such surgery because of poor health, there are also injections and medications that can be used to achieve androgen removal. However, androgen removal therapy does not cure prostate cancer. Prostate cancer cells can slowly adapt to the new internal environment and continue to grow, at which point prostate cancer enters the hormone-independent stage. Many treatments, including radiation therapy, isotope therapy, chemotherapy, and Chinese herbal medicine, can help relieve the symptoms of prostate cancer. Again, it is important to choose the appropriate treatment according to the patient’s specific situation. Emerging clinical trials of targeted therapies are also underway, bringing new options for the treatment of advanced prostate cancer.