Men with hepatitis B who are preparing for pregnancy should take antiviral medications, such as tibivudine, as prescribed by their doctor. Men with hepatitis B should always go to the hospital for liver function tests and HBV-DNA monitoring before preparing for pregnancy. If a man’s liver function is severely impaired and the virus is active, it is not advisable to rush to prepare for pregnancy. Instead, he should actively take antiviral drugs (such as Tenofovir, Entecavir, Tibivudine, etc.) for treatment, and wait until his condition improves and the virus is in a low stage before preparing for pregnancy. And if the woman does not have antibodies, she needs to get the hepatitis B vaccine until enough antibodies are produced. At present, except for interferon, which has been shown to have an adverse effect on male sperm, there is no valid evidence that drugs such as entecavir have an adverse effect on male sperm, and the relevant guidelines also address the fact that women taking the drug may pose a risk of teratogenicity to the fetus. In summary, men with hepatitis B should be actively treated in order to prepare for pregnancy, the specific treatment program and preparation for pregnancy precautions please follow the doctor’s advice, do not blindly self-medication. At the same time, both parties to prepare for pregnancy should develop good habits, quit smoking and alcohol.