1, Diagnosis 1.1, Pathogenetic characteristics IgA nephropathy is the most common primary glomerular disease, is a diagnostic term of immunopathology, a group of primary glomerulonephritis without systemic disease, the histopathological characteristics of the kidney is dominated by thylakoid cells and stromal hyperplasia, immunopathological characteristics of the thylakoid region is dominated by IgA deposition, the main clinical manifestation is hematuria. 1.2, IgA nephropathy urinalysis features 1, simple hematuria (microscopic hematuria or carnivorous hematuria); 2, hematuria with mild or moderate proteinuria; 3, simple proteinuria, or even nephrotic syndrome. The first two clinical conditions are common. IgA nephropathy has normal blood pressure and renal function at the initial onset. Some patients with progressive disease may develop hypertension and renal hypofunction in later stages, and serum IgA values are elevated in about 50% of patients. 1.3, Diagnostic points 1, the onset of most children or young people. 2. Clinical manifestations of renal damage: hematuria, even sarcohematuria and/or varying degrees of proteinuria, with/without acute or chronic renal failure. 3, Characterized by pharyngitis synchronous hematuria and detected as glomerular hematuria. 4.Must have the result of immunopathological examination by renal puncture: IgA is mainly in the glomerular thylakoid area in the form of clumps or scattered coarse particles distribution. 5. Secondary glomerular disease with IgA deposition must be excluded. 2. Renal pathological features 2.1. Light microscopic lesions are mainly in the thylakoid region, with varying degrees of thylakoid cell and stromal hyperplasia. Complex-hemoglobinophilic deposits in the thylakoid region are common. Some of them may be accompanied by varying degrees of tubulointerstitial damage. 2.2. Immunopathology: IgA-based immunoglobulins and C3 are deposited in clumps in the thylakoid region. In some cases, IgA deposits in the capillary wall can be seen, which may be accompanied by IgM, IgG and other immune complexes. 2.3. Electron microscopy 1. Typical features: proliferation of glomerular thylakoid cells, increased thylakoid stroma with clumps of dense electron-dense deposits. In some cases, subendothelial electron-dense deposits can be seen. 3. Differential diagnosis IgA nephropathy should be differentiated from secondary glomerular diseases such as allergic purpura nephritis, cirrhotic kidney damage, and lupus nephritis. Hematuria should also be differentiated from thin basement membrane nephropathy and the hematuria seen in Nutcracker phenomenon. 4. Identification and typing 4.1. Wind-heat of the lung guard, forcing blood downward Main symptoms: fever with slight evil wind-cold, headache and cough, sore throat, red and red urine or microscopic hematuria. The tongue is red with thin white or thin yellow coating, and the pulse is floating. 4.2, Damp-heat in the lower Jiao, forcing blood downward. Main symptoms: abdominal pain, diarrhea, vexation and thirst, or frequent urination, burning and astringent pain, distension and pain in the lower abdomen, dry stools, red and red urine or hematuria under the mirror. The tongue is red, the coating is yellow and greasy, and the pulse is slippery. 4.3, Qi and Yin deficiency symptoms: microscopic hematuria or proteinuria, fatigue, lumbar and knee pain, lack of warmth in the hands and feet or heat in the heart of the hands and feet, spontaneous sweating or night sweating, easy to catch a cold, palpitations, no thirst in the mouth or dry and painful throat, dry or loose stools. The tongue is light red with teeth marks on the edges or the tongue is fat, the coating is thin white or thin yellow and dry, and the pulse is thin and weak. 4.4. Liver and kidney yin deficiency symptoms: microscopic hematuria or proteinuria, irritable heat in the heart, dry and painful pharynx, dizziness of the head and eyes, tinnitus and lumbar pain, dry stools. The tongue is red, the coating is dry, and the pulse is fine or stringy. 4.5. Spleen and kidney Qi deficiency symptoms: microscopic hematuria or proteinuria, fatigue, lumbar and knee weakness, nocturnal urination, loose stools or diarrhea, pale mouth without thirst, pale fat tongue with tooth marks, thin white fur, sunken and weak pulse. 5, I gA nephropathy comprehensive clinical efficacy evaluation criteria.