Tenofovir is a prescription drug, patients have to take the drug under the guidance of the doctor, the duration of medication also need to be determined by the doctor with the patient’s examination results. Tenofovir does not necessarily need to take the drug for life, in most cases need to take 2 years and more, whether the drug can be discontinued mainly according to the patient’s physical condition to decide, can not decide on their own whether to stop the drug. Tenofovir is an antiviral drug, now mainly used in clinical treatment of active chronic hepatitis B, can effectively inhibit the activity of hepatitis B virus DNA, reduce the value of hepatitis B virus DNA, can also be used for the treatment of HIV. tenofovir often need to be taken for a long time, not to stop the drug to avoid rebound or even more serious consequences. Tenofovir common side effects include nausea, vomiting, rash, if the above occurs during the medication is recommended to go to the hospital for examination and active treatment to see if tenofovir needs to be replaced. Patients who have been taking tenofovir for more than 2 years are required to go to the hospital regularly for laboratory tests to check liver function, kidney function, blood calcium level, blood phosphorus level, urine routine, etc. If there is bone pain, X-ray imaging is also needed to clarify whether there is bone softening, and if there is, the drug needs to be discontinued and changed to another drug for treatment.