Medical history and questions: I was checked out in 98 when I had a medical checkup that I was a hepatitis B major triplet, with a dna virus of 1.7*7 times 10 and transaminases to be higher than normal, and I started taking liver-protective drugs, and my liver function reached normal values. Later, when the examination, liver function is not normal again, the doctor prescribed me antiviral drugs – Adefovir, eat a month after the inconvenience of buying drugs on their own to stop, two months later to check, transaminases are very high, the doctor told me to eat antiviral drugs again, eat Adefovir, from August 99 to eat, six months later liver function is normal I have been taking this medicine for five and a half years now, and I have been checked every three or five months since then, and my liver function is normal, and the dna virus is occasionally less than 1*10 to the third power twice, and most of them are below the lower limit of detection. I would like to ask the doctor if I can stop the drug? Analysis and answer: 1. It is necessary to make a comprehensive judgment whether you can stop the medication; and you stopped the medication at will (poor compliance), did not follow up regularly, and many medical history information cannot be obtained. 2. 3.Since the antiviral ability of adefovir is relatively weak, the initial antiviral treatment is not very suitable for applying adefovir in case of high viral load like you, probably because adefovir is cheaper. 4. Adefovir is used as an initial antiviral drug and is more commonly used in China, but the resulting problems of poor response, multidrug resistance, cross-resistance, and impaired renal function are becoming more and more common. Therefore, both doctors and patients should pay attention to this. 5.As adefovir may have an effect on renal function, it is recommended that you check renal function, blood phosphorus, urine routine, β2 microglobulin and other tests as soon as possible to clarify the status of your current renal function. 6.It is recommended to do a hepatitis B virus low copy test, also known as Roche reagent test, to clarify the exact level of hepatitis B virus DNA in your body at present. 5.If the hepatitis B virus DNA is still replicating at a high level, it is recommended to switch to entecavir antiviral therapy as soon as possible.