Kidney insufficiency to take metoclopramide tablets, benadryl tablets and other antiemetic drugs, but severe renal insufficiency should be reduced, and pay attention to observe the side effects of the drug. Metoclopramide tablets can treat various causes of nausea, vomiting, belching (hiccups), dyspepsia, etc.; esophagitis, uremia caused by gastric emptying disorder. Common adverse reactions include drowsiness, restlessness, and fatigue. It is contraindicated in hypersensitivity to procaine (amine), gastrointestinal bleeding and obstruction. The application should be reduced in hepatic and renal failure. Diphenhydramine tablets are an antihistamine, which has a strong depressant effect on the central nervous system and a strong antiemetic effect. Stagnation, sleepiness, poor concentration, fatigue, dizziness, lightheadedness, ataxia, nausea, vomiting, loss of appetite and dry mouth may occur with the use of such drugs. Contraindicated in neonates, preterm infants, women in early pregnancy, breastfeeding women, patients with angle-closure glaucoma, patients with prostatic hyperplasia, bladder neck obstruction, intestinal obstruction, and patients with pyloric and duodenal obstruction. If vomiting occurs in patients with renal insufficiency, it is recommended to go to the hospital in time, complete the relevant examinations under the guidance of the doctor, clarify the cause, symptomatic treatment, and avoid self-medication, so as to avoid adverse consequences and aggravation of the condition.