Serum protein electrophoresis is an electrophoretic method of determining the percentage of total protein that is accounted for by various proteins, and is used clinically in the diagnosis of liver disease, kidney disease, and multiple myeloma. For example, patients with myeloma can show specific proteins, known as M proteins, on protein electrophoresis. And in nephrotic syndrome, α2 globulin increases significantly and albumin decreases; in cirrhosis, γ globulin increases significantly, and γ globulin and β globulin are connected and not easy to be separated, and albumin will show a significant decrease.