In fact, Rosuvastatin calcium tablets, like atorvastatin calcium tablets, can be taken at any time of the day. Most people will pick the morning to take them or take them at night because the morning is a high time for cardiovascular events. In addition, human cholesterol is at a peak at 12:00 a.m. Taking Rosuvastatin at night will allow the blood concentration to reach a better height and provide better clinical efficacy. In fact, taking it in the morning or in the evening can inhibit the synthesis of cholesterol very well. Rosuvastatin is best taken at night because it has a long half-life and can reach a good steady-state blood concentration after 5-7 days at any one time, thus providing good efficacy. It can be taken at any time of the day to inhibit cholesterol synthesis and stabilize arterial plaque. The simple difference between Rosuvastatin Calcium Tablets and Atorvastatin Calcium Tablets is that Atorvastatin Calcium Tablets are fat soluble while Rosuvastatin Calcium Tablets are water soluble, fat soluble drugs easily cross the blood-brain barrier while water soluble drugs are more difficult to cross. And water-soluble drugs are easily metabolized, which may be related to absorption and adverse effects.