The causes of multiple gallstones are complicated, usually the following aspects: First, abnormal secretion of estrogen in the body, especially in women, the secretion of estrogen and progesterone is too high, which will accelerate the secretion of bile, too much bile causes an imbalance in the acidity of total bile, which is very easy to trigger gallstones. Second, patients with poor dietary habits, often eat foods with high fat content, such as animal offal, duck meat, pork, etc., these foods will increase the burden on the digestive system, the bile in the gallbladder will not be smoothly discharged due to reduced muscle tone, thus causing the accumulation of bile caused by stones. People who lose too much weight are also at high risk of multiple gallstones. Due to excessive dieting, bile and cholesterol concentration in the gallbladder will be precipitated and cause gallstones.