Neuropathic pain disorders are a “gift” from mankind and society to clinical medicine, and postherpetic neuralgia, the most representative pain disorder in this field, is a challenge to us. Post-herpetic neuralgia is a pathological pain syndrome resulting from the reactivation of the herpes zoster virus. Despite advances in knowledge of the neurobiology of sensory signals and their central processing, clinical treatment of it is unsatisfactory. Because of its severity and chronic course, postherpetic neuralgia is a major problem affecting the health of patients. A careful analysis of patients with postherpetic neuralgia is mainly the result of viral invasion and damage to the sensory nervous system. The most important reason for being able to produce postherpetic neuralgia lies in the fact that in the early stages we were not able to control the attack of the virus, which led to the erosion and destruction of the peripheral nerves and caused postherpetic neuralgia. Therefore, our clinical focus should be on the early control of the virus. After more than 20 years of research, we have found a fast and effective treatment method to suppress the virus attack. Generally, within the first week of herpes zoster attack, after 1 to 2 treatments, the herpes at the lesion can shrink and the pain can be significantly relieved, and 3 treatments are basically cured. The data of thousands of cases show that basically no postherpetic neuralgia is left. This indicates that post-herpetic neuralgia can be completely avoided by controlling the attack of the virus and the erosion and destruction of the peripheral nerves at an early stage.