Amino-terminal brain natriuretic peptide precursor (NT-proBNP) is a product of B-type natriuretic peptide proteins (proBNP) metabolized in the body and is commonly used to assess cardiac function. When cardiac function is impaired, B-type natriuretic peptide proteins (proBNP) are released, which are metabolized by the body and broken down into NT-proBNP and brain natriuretic peptide (BNP).BNP is a natural antagonist of the renin-angiotensin-aldosterone system, which can regulate blood pressure, blood volume, and water-salt balance, dilate blood vessels, increase the glomerular filtration rate, diuresis, and lower the vascular resistance of the body circulation, and other functions of cardiac function maintenance. BNP can be used to assess cardiac function. BNP can be used as an indicator to assess cardiac function, but in clinical cases of heart failure, exogenous BNP is often supplemented, such as natriuretic peptide injection, etc., so the index of BNP will be affected, and it can not objectively reflect the real cardiac function of the patient. NT-proBNP, as a metabolite of proBNP, is not affected by drugs, so it is commonly used in clinical practice to assess the function of the heart. NT-proBNP is usually used to reflect the function of the heart, and there are different criteria according to different ages, which should be interpreted by specialized doctors in conjunction with the patient’s condition.