The manifestations of severe nephrotic syndrome are mainly the high accumulation of water and fluid and the occurrence of complications. The high accumulation of water and fluid is mainly manifested by high subcutaneous swelling and even skin ooze, but also by the accumulation of fluid in multiple plasma cavities, such as pleural fluid, ascites, and pericardial fluid. Complications are mainly the occurrence of infection, thromboembolism, and acute kidney injury. For this condition, patients are generally advised to rest in bed as much as possible and to perform activities in bed to prevent thrombosis. A low-salt diet is recommended, with a salt intake of <3g per day, along with a high-quality protein supplement, with a protein intake of 0.8-1g/kg per day, and appropriate vitamin or trace element supplementation. If there is severe hypoproteinemia and insufficient effective blood volume, plasma products or plasma substitutes will be supplemented for volume expansion treatment, followed by diuretics to reduce swelling. There are also ACEI drugs or ARB drugs to control urinary protein excretion, and lipid regulating drugs for lipid lowering treatment, and more specifically glucocorticoids or immunosuppressive drugs. If you find yourself with the above symptoms, it is recommended that you seek treatment from a specialist at a hospital.