How to check and confirm the diagnosis of Magee syndrome?

       Magee’s syndrome refers to a patient with ovarian fibroma with pleural effusion and ascites, which may be bloody. After the tumor is removed, the pleural effusion and ascites can disappear one after another.  Symptoms of the disease 1. There is no significant difference in the incidence of ovarian tumor between right and left side, according to statistics, 1%-40% of ovarian fibroma patients can be complicated by ascites. 2. Pleural effusion can occur on the same side of ovarian tumor or on the opposite side, among which 62% can be seen on the right side of the chest, 11% on the left side, and 24% on both sides of the chest. Despite repeated thoracic and abdominal puncture and aspiration, the fluid still grew rapidly. After tumor removal, the pleural fluid and ascites disappeared by themselves.  3.Patients with ascites may not be complicated with pleural effusion at the same time. Some cases only have ascites without pleural effusion, or had pleural effusion, but it disappeared later.  4. Pleural effusion and ascites are mostly leaking fluid, and a few of them can be exudate with a density (specific gravity) of 0.010 to 1.017. There is no relationship between the amount of fluid and tumor size. However, tumors with combined pleural effusion and ascites are larger, generally with diameter over 10 cm. the amount of pleural effusion and ascites varies, and can cause pressure symptoms and signs when there are more than one. when tumor bleeds, ascites can be bloody.  5.Abdominal pain, abdominal distension, cough, chest tightness, chest pain, shortness of breath, inability to lie down, lower limb edema, urinary incontinence, weight loss, and vaginal bleeding may occur.  6.Physical examination shows solid sound on lung percussion, diminished breath sounds, positive ascites sign, and the patient prefers to lie on the right side. The ovarian mass, which is characterized by a hard, stone-like texture, is of medium size, usually larger than 10 cm, with a smooth surface, good mobility and no pressure pain.  7. The mass can often be complicated by substantial tumors of the ovary, such as ovarian fibroma, smooth muscle tumor, follicular membrane tumor and ovarian fibroepithelioma.  According to the symptoms and signs, gynecological examination, ovarian tumor is found to be hard in texture and combined with thoracoabdominal effusion (not necessarily thoracoabdominal effusion at the same time) should be considered the syndrome, and if the ovarian tumor is surgically confirmed to be fibroma, the diagnosis can be confirmed.  Disease examination 1. Biochemical examination of ascites is mostly leakage fluid, clear or yellowish, specific gravity is mostly 1.010~1.017, cell count is often less than 400×106/L, protein amount is often less than 0.3g/L. 2. Blood and ascites tumor markers are not abnormal.  3, ascites by ascites cytology, cell chromosome examination, AgNOR detection, flow cytometry and imaging analysis all suggest benign ascites.  4, Biochemical identification of ascites such as specific gravity, ascites protein amount, lactate dehydrogenase (LDH) and ascites-serum LDH ratio (ASLR), adenosine deaminase (ADA), ferritin (FA) and ascites-serum ferritin ratio, all suggest benign ascites.  5, ascites immunological tests such as CA125, β-microglobulin, etc. to identify the nature of ascites.  6, abdominal ultrasound examination can be seen on the side of the adnexa with moderate or enhanced echogenic area, more homogeneous quality, medium size, no clear cystic wall, pelvic or abdominal cavity, with liquid dark area.  7.X-ray examination of fibroma also shows calcified areas, and pleural effusion also has X-ray signs.  8.Laparoscopy.  9.Histopathological examination.  Prevention Early detection, early surgical treatment and attention to follow-up.  Treatment Preoperative preparation: improvement of the patient’s general condition, selection of anesthesia, instruments and related medications, and emergency measures. The mode, scope and specific operation of surgery depend on the patient’s age and the nature and size of the tumor, unilateral or bilateral growth, and whether there are adhesions or malignant metastases.