Early prostate cancer often has no uncomfortable symptoms, much less prostate cancer-specific features and symptoms. In the early stages of prostate cancer, your health is not affected in any way and there is no evidence or discomfort to suggest that you have prostate cancer.PSA is a highly sensitive prostate-specific antigen. Generally, elevated PSA is often found during a physical examination and is an indication for a prostate puncture biopsy. However, not all prostate cancer patients have an elevated PSA. A small percentage of prostate cancer patients have a serum PSA that is within the normal range, which tells us how important it is for your doctor to perform a rectal exam. When a fixed nodule is found on rectal examination, we recommend the need for a prostate puncture biopsy even if the serum PSA value is within the normal range. The combination of serum PSA and rectal examination is currently the best means of screening for prostate cancer. In a small number of cases, prostate cancer cells are found on pathological examination after TURP and open prostatectomy, and the diagnosis of prostate cancer (incidental prostate cancer) is made in 10-15% of cases. If prostate cancer is not diagnosed or detected in time in the early stage, when prostate cancer progresses to advanced stage, it is often diagnosed as prostate cancer due to late manifestations such as bone pain, urinary tract obstruction, wasting or hematuria.