Pregnancy is a special time when the body’s hormone levels change dramatically, the body’s immune system is suppressed, metabolic levels increase, and therefore the burden on the liver is increased, and pregnancy may precipitate or exacerbate hepatitis episodes. Therefore, it is important to choose a good time to get pregnant so as not to exacerbate the deterioration of the condition, and pregnancy at an inappropriate time will also be more contagious. Hepatitis B patients need to get pregnant when liver function is normal and HBV-DNA is negative, pay attention to regular review during pregnancy, do not use drugs and supplements indiscriminately, and do a good job of mother-to-child interruption.