Partial atypical hyperplasia of the endometrium needs to be managed differently in relation to the specific age of the woman and the corresponding history of pregnancy and childbirth. In women >45 years of age with no childbearing potential, hysterectomy may be considered to interrupt the progression of the lesion. For young women with childbearing requirements, in response to these findings, high potency progestins or low doses of progestins in the intrauterine slow release system can be administered to inhibit the progression of the disease, and the endometrial pathology in the uterine cavity needs to be monitored regularly during the drug application process.