Thyroid peroxidase antibody 600IU/L may be Hashimoto’s thyroiditis, and treatment is needed if hypothyroidism is present. The reference range for thyroid peroxidase antibodies (TPOAb) is 0-34 IU/L. 600 IU/L is higher than normal, suggesting autoimmune inflammation, and most cases of Hashimoto’s thyroiditis are positive for TPOAb. There is no treatment for the cause of the disease, and limiting iodine intake may help to stop the progression of autoimmune destruction of the thyroid. If there are no clinical symptoms and no hypothyroidism, Hashimoto’s thyroiditis does not require treatment, and regular follow-up is sufficient; if hypothyroidism occurs, such as fatigue, chills, drowsiness, etc., thyroid hormone replacement therapy is required under the supervision of a doctor. Elevated thyroid peroxidase antibodies need to be examined and treated under a doctor’s supervision.