After infection with the hepatitis B virus, different clinical manifestations are caused by the different immune status of individuals and differences in lifestyle. A significant proportion of people have no clinical symptoms or only mild abdominal discomfort, so many people do not pay enough attention and do not go for long-term checkups and follow-ups, which is detrimental to the observation of the disease. For patients with hepatitis B, how often should they be rechecked? First of all, for patients who are asymptomatic and untreated, this group of people is most likely to neglect follow-up and review. If the liver function is completely normal, and the abdominal ultrasound does not indicate cirrhosis, and the liver hardness value test does not indicate liver fibrosis, then you can review the liver function, hepatitis B 2.5, HBV-DNA every six months or so, and every year you should have a comprehensive review, including liver function, hepatitis B 2.5, HBV-DNA, abdominal ultrasound, liver fibrosis test (liver hardness value), and alpha-fetoprotein. Some people may think that I am fine, no symptoms, no need to check. If there are long-term lesions in the liver, there will be a process from quantitative to qualitative changes, and the risk of cirrhosis and liver cancer will be greatly increased. Especially for people over 40 years old, it is more important to increase the frequency of review. For patients who are already on oral nucleoside analog antiviral, they need to be reviewed every three months to find out the efficacy of the drug, any drug resistance, etc. Some patients think that they don’t need to be reviewed because they have already been treated. It is important to know that nucleoside analogs are not effective for everyone, some people start to be effective, but then resistance occurs and becomes less effective or ineffective. In the process of medication, it is also necessary to observe whether there are adverse reactions, so regular follow-up is indispensable. In the case of outpatient treatment for liver function abnormalities, liver function should be rechecked after one month of oral medication to understand changes in the condition. Of course, if the condition has significantly worsened, immediate hospitalization is necessary.