Hepatitis B virus (HBV) infection not only causes acute and chronic hepatitis and hepatic steatosis, but also can eventually lead to hepatocellular carcinoma (HCC) due to persistent HBV infection and host immune response. In our clinical practice, we found that 95% of patients with hepatocellular carcinoma are accompanied by hepatitis B. In other words, the long-term chronic damage caused by hepatitis B virus plays a very important role in the development of hepatocellular carcinoma. In our daily treatment, patients with hepatocellular carcinoma often come to the hospital only because they are not feeling well, at which time the examination results often indicate that the disease is already at an advanced stage and it is difficult to carry out radical treatment. If radical treatment is not available, the prognosis of patients can be imagined. Therefore, for hepatitis B patients, it is important to develop the habit of regular checkups, so that liver cancer can be detected in time. Most of the liver cancers detected by such medical checkups are in early stage, which can get radical treatment and their treatment effect will be very good. Then, how often should hepatitis B patients be examined? I think it is more appropriate to check once every three months. If there is any abnormality in the test result, the interval of the test should be shortened and contact with the specialist in time. What is the content of each test? Routine blood tests (to find out the number of white blood cells, red blood cells, hemoglobin and platelets), liver function (including transaminases, albumin and bilirubin levels), alpha-fetoprotein (AFP), hepatitis B virus replication (HBV-DNA quantification), and ultrasound examination of the liver and gallbladder (CT or MRI of the liver and gallbladder if necessary).