Patients with hepatitis B often have some cognitive misconceptions, and it is these cognitive biases that lead to psychological or pathological damage, which is sometimes more powerful than the disease itself. So this issue will talk about this topic. 1, think that “small three positive” is fine. For such patients, we need to look at the HBV-DNA replication, if it is high, it will also lead to disease progression; if it is not measured, we call it “inactive carriers” and the disease will be relatively quiescent, which is also the goal of our clinicians’ treatment. 2, think that high HBV-DNA lesions are serious; HBV-DNA can not be measured, it is fine. The lesions are closely related to the level of HBV-DNA, but not in a parallel way, and it must depend on the liver function at this time. Generally speaking, if the transaminase is high and the HBV-DNA is high, the lesion is serious. If the HBV-DNA is high and the transaminase is normal, it does not mean that the disease is more serious than that of a person with low HBV-DNA, there may be no difference, or even the lesion is lighter, because the lesion of hepatitis B is very much related to the immunity of the individual, which means that there are great individual differences. Clinicians often encounter patients with high HBV-DNA who have not developed cirrhosis or liver cancer by the age of 60 or 70.