Homemade milkshake is a mixture of milk, fruit, ice, moderate drinking does not affect health, long-term large quantities of homemade milkshake may cause gastrointestinal discomfort, malnutrition, endocrine disruption and other hazards. 1. gastrointestinal discomfort: due to the homemade milkshake belongs to the cold drinks, long time drinking homemade milkshake may cause stimulation of the gastrointestinal tract, thus appearing abdominal pain, diarrhea, indigestion, etc., and the serious cases may also cause acute gastroenteritis and so on. 2. Malnutrition: milkshake is generally processed from milk, fruit, ice, its nutrient composition is relatively single, long-term drink homemade milkshake may cause nutritional intake is insufficient, causing malnutrition. 3. Endocrine disorders: long-term drink milkshake meal replacement may be in a short period of time, a significant reduction in body weight, but the weight loss is too fast will lead to endocrine disorders, resulting in menstrual disorders, amenorrhea, hair loss and so on. It is recommended that people with abnormal gastrointestinal function and low body weight try to avoid consuming large quantities of homemade milkshake for a long period of time, and follow a scientific diet in their lives, eat a light diet, pay attention to dietary combinations, and try to minimize the consumption of fried and puffed up food, sweets, greasy food, etc.