The difference between lipoma and cyst is mainly due to the different nature and treatment methods, as follows: 1. The nature of lipoma and cyst is different; lipoma is caused by the abnormal local convergence of fat particles in the body, which increases in size and size, and is a solid mass, which generally grows slowly and does not lead to obvious pain or skin redness and swelling, while cyst is a kind of cyst. Cysts are cystic masses, which may contain infectious fluid, blood, or lymphatic fluid; 2. Cysts usually do not require surgery, and the treatment can also choose puncture and drainage of cysts, or complete removal of cysts.