Botulinum toxin is a bacterial exotoxin produced by Clostridium botulinum in the process of reproduction, which is divided into many subtypes, and basically all of them are type A botulinum toxin used in cosmetic operations. The normal muscle contraction process is: nerve impulse → acetylcholine → end plate potential → muscle action potential → muscle contraction Botulinum toxin can interfere with the release of acetylcholine to block the conduction of nerve impulses to the muscle, to achieve the effect of paralysis of the muscle. Safety: The LD50 of botulinum toxin type A is 40 units/kg, and the maximum amount of clinical cosmetic application is not more than 400 units, which is a trace level. As Botulinum toxin type A has strong nerve cell selectivity, the limited toxin binds to the nerve terminal receptors and rarely enters the bloodstream. Therefore, the clinical cosmetic application is very safe. Product type: There are only two types of botulinum toxin approved to be marketed in China: 1, BTX-A: domestic brand, 100 units/pcs 2, BOTOX (BOTOX): American brand, 100 units/pcs 4, indications: 1, muscle contour shaping: thin face, thin calves; 2, wrinkle removal (dynamic wrinkles): forehead lines (head lines), frown lines (Kawasaki lines), corner lines (crow’s feet), lower lid 3.Facial lifting: lifting the eyebrows, lowering the upper lip (gingival smile correction), lifting the corners of the mouth (correction of sagging corners of the mouth), chin release (improve the chin folds); 4.Hand and foot hyperhidrosis treatment. V. Contraindications: 1, allergic to any component of botulinum toxin products or human albumin; 2, suffering from neuromuscular diseases such as myasthenia gravis and Lambert-Eaton syndrome; 3, pregnant and lactating women should not be used; 4, unrealistically high expectations for treatment. Precautions before treatment; 1, aminoglycoside antibiotics (such as gentamicin, etc.) can enhance the effect of botulinum toxin, the application of such antibiotics should be stopped before injection; 2, do not use aspirin, non-steroidal anti-inflammatory drugs and other drugs that inhibit platelet function, especially the need to inject deep muscle groups (such as thin calves); 3, always have epinephrine, in case of occasional allergic reactions in the first aid, after injection treatment should stay in the hospital Observation for at least 15 minutes after injection treatment.