Altitude sickness is a kind of alpine disease, also known as plateau acclimatization insufficiency, mainly due to the plateau low oxygen environment caused by the disease, clinical dizziness, palpitations, shortness of breath and other symptoms. Currently, treatment options include oxygen therapy, off-site treatment, medication, and so on. Low air pressure and low oxygen environment may cause altitude sickness. Thin air is the characteristic of plateau environment, and the increase of altitude will lead to the decrease of air pressure, so altitude sickness may occur. The main clinical symptoms of altitude sickness are shortness of breath, palpitations, dizziness, headache, lack of appetite, nausea and vomiting. The main options for treating altitude sickness are rest, oxygen intake, and off-site treatment, such as transferring to live in an area with low sea level and choosing low-flow oxygen intake. Medications are also available, including ibuprofen or aspirin for headaches and mepecromazine for nausea and vomiting. The use of medication should be in accordance with the doctor’s instructions, and should not be used blindly. Plateau disease, if not improved in time, may also have plateau pulmonary edema, plateau cerebral edema, etc., the situation is more serious, so it is recommended to go to the emergency department of the hospital in time for treatment.