The treatment of scratchy urticaria is based on the same principles as the conventional treatment of urticaria, and the main medication is also antihistamines. Second-generation antihistamines are weaker due to their inhibitory effect on the central nervous system, such as loratadine tablets, azelastine hydrochloride tablets and levocetirizine hydrochloride, all of which have systemic anti-allergic effects and are generally used mostly in the treatment of chronic urticaria. The main thing should also be to remove the cause of the disease, or if that is not possible, to reduce the various factors that promote the onset of the disease. Even if the cause cannot be found in many patients with chronic urticaria, medication can often bring the disease under control or cure. If the effect of simple antihistamines is not satisfactory, H2 receptor antagonists, such as ranitidine, or drugs that stabilize the mast cell membrane, such as trinostat, can be added according to the condition of the combined application, which can also generally achieve good results. Recurrent episodes of chronic urticaria may require long-term medication. In order to avoid its development of drug resistance, a different type of antihistamine can be substituted when the application of a certain drug is ineffective. If chronic urticaria is controlled, patients can also take a gradual reduction or even discontinuation of the medication to maintain remission. Therefore, scratch urticaria is usually slow and can be treated with antihistamines for symptomatic desensitization. If there is an acute attack, other drugs such as glucocorticoids may be applied.