There are two possibilities for pustules on the soles of the feet: the first one may be palmoplantar pustulosis, and this pustule is a sterile inflammatory disease. In clinical treatment, you can take oral compound glycopyrrolate capsule 3 times/day, 2 capsules/time, and apply topical halomethasone ointment 1:1 mixed with butyl flufenamic acid ointment, 2 times/day for treatment. If the pustules appear as large nodules, or the inflammatory manifestation of tiny follicular consistency, consider the possibility of folliculitis or boils is more likely, at this time mainly consider bacterial infection caused. The clinical treatment requires oral amoxicillin capsules or roxithromycin capsules and topical application of compound polymyxin B ointment, applied 2 times/day for treatment.