The cranium is a hard protective shell for the human brain, which is responsible for the safety of the brain tissue from external aggressions. However, cranial defects are a frequent occurrence nowadays, and many people suffer from cranial defects due to traffic accidents or falling objects, which have a great impact on safety and health. Cranial defects need to be taken seriously and it is crucial to go to the hospital for cranial repair surgery as soon as possible. When it comes to skull repair surgery, patients are always worried about the risk of surgery. In fact, there is no need to worry too much about the safety of cranial repair surgery, it is a very developed neurosurgical procedure that has been tested over time and has become more advanced and mature in terms of technology and materials. However, patients should be cautious and need to go to a regular hospital and choose an experienced specialist to perform the surgery in order to achieve good results. Of course, there is another key factor that affects the outcome of skull repair surgery, and that is the choice of repair material. From the past to the present, the use of skull repair materials has been constantly changed, from bone cement and plexiglass at the beginning to the more common titanium mesh materials nowadays, which are not expensive, but the surgical effect may still have some defects and some problems may occur after the surgery, so it is not recommended to use them anymore. Nowadays, peek material is the ideal material for skull repair surgery, which is an advanced polymer material with excellent performance, hard and elastic, high stability, strong histocompatibility, personalized three-dimensional shaping, and can better restore the integrity and beauty of the skull. peek material’s price is relatively high, but it is proportional to the surgical effect.