The repeated growth of closed mouth acne is generally due to the oil secretion is blocked in the hair follicles formed, can be improved through the use of topical drugs, physical therapy and general treatment. 1. Topical medication: A thin layer of retinoic acid cream or adapalene gel can be applied on the closed mouth acne to promote the dissolution of acne; if the closed mouth acne is in patches and the area is relatively large, it can be improved with oral isotretinoin capsules. 2. Physical therapy: laser treatment, fruit acid peeling or salicylic acid chemical peeling can be used to inhibit the secretion of sebaceous glands, so as to clear up the closed mouth acne. 3. General treatment: In daily life, we should pay attention to a light diet, eat less spicy, greasy food and too much sweet food, keep the bowel movement every day, regular work and rest, do not stay up all night. At the same time, pay attention to skin cleanliness, hygiene, to avoid the accumulation of oil, dirt. It is recommended that patients with recurring closed mouth acne go to a regular hospital, under the guidance of a professional doctor to standardize the treatment, and not blindly use their own medication.