Tumor markers of pancreatic cancer Pancreatic cancer cells can secrete some glycoproteins, which are commonly used clinically, including CA19-9, CA242, CA724, CA50, CEA, DU-PAN-2, Span-1 and IAP, etc. However, the specificity of these markers is low, and their increase is also seen in hepatic, biliary, gastrointestinal, gallbladder carcinomas and non-digestive tract (lung, ovarian) cancers, and occasionally in chronic pancreatitis and Acute cholangitis. The reason is that malignant tumors of epithelial origin contain some glycoproteins, which are not specific to a particular tumor, and normal epithelial tissues also contain these glycoproteins, only at lower levels than tumors. For high-risk patients, CA19-9 or CA19-9, CA242, CA724, CA50 can be used as a screening test. Most of the above tumor markers drop to normal after complete resection of the pancreas and increase again in case of recurrence.