Many patients often ask the question “can chronic hepatitis B be completely cured”. Most patients say that a complete cure should mean that the hepatitis B virus is completely cleared, the surface antigen is negative, and there is no recurrence in the future. Objectively speaking, there are no effective drugs that can achieve such a desirable goal that patients expect. However, with scientific and reasonable treatment, most patients can control the progression of the disease and reverse the degree of liver lesions (including cirrhosis) to a certain extent. Therefore, with regard to the current state of treatment for chronic hepatitis B, each patient should carefully analyze his or her condition and determine his or her own treatment goals with the help of a physician, and it is unrealistic to blindly pursue a complete cure for hepatitis B. Listening to false advertisements and unregulated treatment not only causes financial losses, but also may bring trouble to the future antiviral treatment.