The hepatitis B virus DNA test is the most reliable way to determine the active replication of the hepatitis B virus and is the basis for clinical antiviral therapy. Currently, hepatitis B virus DNA testing is becoming more and more common in hepatitis B screening tests. Hepatitis B virus DNA testing is usually divided into two types of tests: qualitative and quantitative, which are used to determine whether the hepatitis B virus is replicating. The qualitative hepatitis B virus test results are only positive and negative, with a positive result indicating a high level of virus in the patient’s body, a high level of replication and a high level of infectivity, and a negative result indicating the opposite. The quantitative hepatitis B virus DNA test result is expressed as an exact value, and the reference value varies with the application of different testing reagents and testing methods. If the quantitative HBVDNA test result is less than the reference value, there are no obvious symptoms and no obvious inflammation of the liver, the patient can be said to have achieved clinical cure. If the HBVDNA test result is greater than the reference value, it indicates the presence of hepatitis B virus replication, and whether antiviral treatment is needed depends on the results of the clinician’s comprehensive assessment. The purpose of regular hepatitis B virus DNA tests for hepatitis B patients is to provide a basis for treatment and to develop a specific and reasonable treatment plan, so try to go to a regular hospital for a review on time.